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Rapid Increase in Tuberculosis Incidence Soon after Infection with HIVA New Twist in the Twin Epidemics

Non HST

 

Publication Information

1st Author : Srikantiah, Padmini
Other Authors: Charlebois E, Havlir D.V
Publisher: Journal of Infectious Diseases
Publication Date: 0/2005
ISBN:
ISSN:
Publication Type: Journal
Series: Journal of Infectious Diseases
Issue: 2005

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Summary Over the course of the AIDS pandemic, we have learned a considerable amount about the intersection of HIV infection and tuberculosis (TB). TB is a leading cause of death among people living with HIV worldwide, 14 million people are coinfected with Mycobacterium tuberculosis and HIV.
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Previous studies have suggested the possibility that TB incidence may increase soon after infection with HIV, but these studies have lacked the power to quantify a statistically significant risk. There were several features of the cohort analyzed by Sonnenberg et al. that enabled them to evaluate the temporal risk pattern of TB after HIV seroconversion: the incidence of TB in the cohort was very high, and the cohort had a high rate of HIV seroconversion. Sonnenberg et al. were able to examine outcomes among 23,874 miners, including 2737 miners with documented HIV seroconversion. TB diagnostic capacity permitted the definitive diagnosis of TB, and the cohort had consistent access to reliable health care.

In the study, miners who were tested for HIV at sexually transmitted disease (STD) clinics, during hospitalization, or as part of seroprevalence surveys during the designated study period were eligible for enrollment. Miners were followed until they developed pulmonary TB, died, or left the mines. HIV-negative miners were also censored from analysis at 1 year after the last negative HIV test. TB was detected during routine annual screenings or patient-initiated visits to the hospital or an STD clinic. Throughout the study period, repeat HIV tests were performed primarily during patient-initiated visits to the hospital or STD (or other) clinics, as well as during seroprevalence surveys.

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Keywords This Item is associated with the Following Keywords: TB, HIV/AIDS.
   
   
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